Pemanfaatan UTILIZATION OF RED MELINJO PEEL (Gnetum gnemon L.) FERMENTED BEVERAGE TOWARDS THE URIC ACIDS LEVEL ON WISTAR RATS
DOI:
https://doi.org/10.53091/jtir.v1i2.25Keywords:
Melinjo Peel, Fermented beverage, uric acid, wistar rats, allopurinolAbstract
Red melinjo peel contains phenolic and flavonoid compounds which can reduce uric acid levels in the bloodstream and urine. The purpose of this research was to determine the effect of red peel melinjo fermented beverage toward the uric acid level in bloodstream and urine of wistar rats. Fermented beverage was added with Lactobacillus acidophilus, Streptococcus thermophilus, dan Lactobacillus casei (1:1:1, 1:1:2, 1:2:1, 2:1:1 4%). The formulation of fermented beverage consist of red peel melinjo extract 4%, skim milk 5% and sugar (4, 6, 8, 10%). Ratio of 1:1:1 and sugar 4% was the chosen formulation based on pH value, total titradable acidity and total lactic acid bacteria. Phenolic and flavonoid content was also being analyzed on the chosen formulation of fermented beverage. The fermented beverage with extract 4% was given to wistar rats to determine the effect towards uric acid levels on bloodstreams and urine. Kidney and liver function was also being analyzed by measuring the SGPT, SGOT, kreatinin and BUN values on wistar rats. The result showed that the fermented beverage can reduce the uric acid levels on bloodstream as much as 55.1±1.01% and 59.,9±1.,21% on urine. Extract 4% can also reduce the uric acid levels on bloodstream as much as 49.,62±3.34% and 59.,57±1.45% on urine. Allopurinol can reduce the uric acid level on bloodstream by 54.97±2.78% and 60.45±1.07% on urine. The research was normal conclude that red melinjo peel was as effective as allopurinol to reduce the uric acid levels on bloodstream and urine. The SGPT, SGOT, kreatinin and BUN value also in the normal value so the kidney and liver function of wistar rats
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